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paav cag mruby2 addgene plasmid  (Addgene inc)


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    Addgene inc paav cag mruby2 addgene plasmid
    Paav Cag Mruby2 Addgene Plasmid, supplied by Addgene inc, used in various techniques. Bioz Stars score: 93/100, based on 7 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/paav+cag+mruby2+addgene+plasmid/pAAV-CAG-mRuby2+(Plasmid+%2399123)/pm41713415-621-200-201
    Average 93 stars, based on 7 article reviews
    paav cag mruby2 addgene plasmid - by Bioz Stars, 2026-09
    93/100 stars

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    Purification:

    Article Title: Liver exerkine reverses aging- and Alzheimer's-related memory loss via vasculature.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER PureLink RNA Mini kit Thermo Fisher Cat#12183025 Direct-zolTM RNA Purification Kit, Miniprep Plus Zymo Research Cat#R2072 High Capacity cDNA Reverse Transcription kit Thermo Fisher Cat#4374966 PowerUp SYBR Green Master Mix Thermo Fisher Cat#A25742 ZebaTM Spin Desalting Columns, 7K MWCO, 5 mL Thermo Fisher Cat#89892 Miltenyi Neural Dissociation Kits (P) Miltenyi Cat#130-092-628 Deposited data Single-nucleus RNA sequencing data This paper GEO: GSE304483 BEC single-cell RNA sequencing data This paper GEO: GSE269061 Experimental models: Cell lines 293T ATCC Cat#CRL-3216; RRID: CVCL_0063 Neuro-2a ATCC Cat#CCL-131; RRID: CVCL_0470 Experimental models: Organisms/strains C57BL/6J The Jackson Laboratory Strain#000664 C57BlL6/J NIA Aging mouse colony NIA N/A 5xFAD (B6SJL-Tg(APPSwFlLon, PSEN1*M146L*L286V)6799Vas/Mmjax) The Jackson Laboratory/ MMRRC MMRRC Strain#034840-JAX B6;129-Gt(ROSA) 26Sortm1(CAG-cas9*,-EGFP)Fezh/J The Jackson Laboratory Strain#024857 Oligonucleotides Gpld1 qPCR FWD: GGAAGCAGAGAGGAATTGTGGC Horowitz et al.16 N/A Gpld1 qPCR REV: TCCAAACCACGAGAAGTCCTCC Horowitz et al.16 N/A Gapdh qPCR FWD: GGGTGTGAACCACGAGAAAT This paper N/A Gapdh qPCR REV: ACTGTGGTCATGAGCCCTTC This paper N/A GPLD1 qPCR FWD (human) This paper N/A GPLD1 qPCR REV (human) This paper N/A Alpl qPCR FWD: GAACAGACCCTCCCCACGAG This paper N/A Alpl qPCR REV: GTGCCGATGGCCAGTACTAA This paper N/A Alpl qPCR FWD2: TAACACCAACGCTCAGGTCC This paper N/A Alpl qPCR REV2: TGGATGTGACCTCATTGCCC This paper N/A Recombinant DNA pAAV2/8 Addgene Plasmid#112864 pUCmini-iCAP-PHP.V1 Addgene Plasmid#127847 pAAV-CAG-mRuby2 Addgene Plasmid#99123 pEMS1938 Addgene Plasmid#82563 pAdDeltaF6 Addgene Plasmid#112867 pMD2.G Addgene Plasmid#12259 psPAX2 Addgene Plasmid#12260 lentiCRISPR v2 Addgene Plasmid#52961 pTB CMV Gpld1 IRES eGFP Horowitz et al.16 N/A pTB CMV Gpld1 H133N IRES eGFP Horowitz et al.16 N/A pTB CMV Gpld1 H158N IRES eGFP Horowitz et al.16 N/A pTB CMV IRES eGFP Horowitz et al.16 N/A pTB CMV Alpl IRES eGFP This paper N/A pTB CMV GPLD1 (human) IRES eGFP This paper N/A pAAV-CAG-Alpl This paper N/A pAAV-CRE-hU6-gRNA This paper N/A pAAV TBG eGFP This paper N/A (Continued on next page) ll OPEN ACCESS e2 Cell 189, 1–18.e1–e9, March 5, 2026 Please cite this article in press as: Bieri et al., Liver exerkine reverses aging- and Alzheimer’s-related memory loss via vasculature, Cell (2026), https://doi.org/10.1016/j.cell.2026.01.024 Article

    Reverse Transcription:

    Article Title: Liver exerkine reverses aging- and Alzheimer's-related memory loss via vasculature.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER PureLink RNA Mini kit Thermo Fisher Cat#12183025 Direct-zolTM RNA Purification Kit, Miniprep Plus Zymo Research Cat#R2072 High Capacity cDNA Reverse Transcription kit Thermo Fisher Cat#4374966 PowerUp SYBR Green Master Mix Thermo Fisher Cat#A25742 ZebaTM Spin Desalting Columns, 7K MWCO, 5 mL Thermo Fisher Cat#89892 Miltenyi Neural Dissociation Kits (P) Miltenyi Cat#130-092-628 Deposited data Single-nucleus RNA sequencing data This paper GEO: GSE304483 BEC single-cell RNA sequencing data This paper GEO: GSE269061 Experimental models: Cell lines 293T ATCC Cat#CRL-3216; RRID: CVCL_0063 Neuro-2a ATCC Cat#CCL-131; RRID: CVCL_0470 Experimental models: Organisms/strains C57BL/6J The Jackson Laboratory Strain#000664 C57BlL6/J NIA Aging mouse colony NIA N/A 5xFAD (B6SJL-Tg(APPSwFlLon, PSEN1*M146L*L286V)6799Vas/Mmjax) The Jackson Laboratory/ MMRRC MMRRC Strain#034840-JAX B6;129-Gt(ROSA) 26Sortm1(CAG-cas9*,-EGFP)Fezh/J The Jackson Laboratory Strain#024857 Oligonucleotides Gpld1 qPCR FWD: GGAAGCAGAGAGGAATTGTGGC Horowitz et al.16 N/A Gpld1 qPCR REV: TCCAAACCACGAGAAGTCCTCC Horowitz et al.16 N/A Gapdh qPCR FWD: GGGTGTGAACCACGAGAAAT This paper N/A Gapdh qPCR REV: ACTGTGGTCATGAGCCCTTC This paper N/A GPLD1 qPCR FWD (human) This paper N/A GPLD1 qPCR REV (human) This paper N/A Alpl qPCR FWD: GAACAGACCCTCCCCACGAG This paper N/A Alpl qPCR REV: GTGCCGATGGCCAGTACTAA This paper N/A Alpl qPCR FWD2: TAACACCAACGCTCAGGTCC This paper N/A Alpl qPCR REV2: TGGATGTGACCTCATTGCCC This paper N/A Recombinant DNA pAAV2/8 Addgene Plasmid#112864 pUCmini-iCAP-PHP.V1 Addgene Plasmid#127847 pAAV-CAG-mRuby2 Addgene Plasmid#99123 pEMS1938 Addgene Plasmid#82563 pAdDeltaF6 Addgene Plasmid#112867 pMD2.G Addgene Plasmid#12259 psPAX2 Addgene Plasmid#12260 lentiCRISPR v2 Addgene Plasmid#52961 pTB CMV Gpld1 IRES eGFP Horowitz et al.16 N/A pTB CMV Gpld1 H133N IRES eGFP Horowitz et al.16 N/A pTB CMV Gpld1 H158N IRES eGFP Horowitz et al.16 N/A pTB CMV IRES eGFP Horowitz et al.16 N/A pTB CMV Alpl IRES eGFP This paper N/A pTB CMV GPLD1 (human) IRES eGFP This paper N/A pAAV-CAG-Alpl This paper N/A pAAV-CRE-hU6-gRNA This paper N/A pAAV TBG eGFP This paper N/A (Continued on next page) ll OPEN ACCESS e2 Cell 189, 1–18.e1–e9, March 5, 2026 Please cite this article in press as: Bieri et al., Liver exerkine reverses aging- and Alzheimer’s-related memory loss via vasculature, Cell (2026), https://doi.org/10.1016/j.cell.2026.01.024 Article

    SYBR Green Assay:

    Article Title: Liver exerkine reverses aging- and Alzheimer's-related memory loss via vasculature.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER PureLink RNA Mini kit Thermo Fisher Cat#12183025 Direct-zolTM RNA Purification Kit, Miniprep Plus Zymo Research Cat#R2072 High Capacity cDNA Reverse Transcription kit Thermo Fisher Cat#4374966 PowerUp SYBR Green Master Mix Thermo Fisher Cat#A25742 ZebaTM Spin Desalting Columns, 7K MWCO, 5 mL Thermo Fisher Cat#89892 Miltenyi Neural Dissociation Kits (P) Miltenyi Cat#130-092-628 Deposited data Single-nucleus RNA sequencing data This paper GEO: GSE304483 BEC single-cell RNA sequencing data This paper GEO: GSE269061 Experimental models: Cell lines 293T ATCC Cat#CRL-3216; RRID: CVCL_0063 Neuro-2a ATCC Cat#CCL-131; RRID: CVCL_0470 Experimental models: Organisms/strains C57BL/6J The Jackson Laboratory Strain#000664 C57BlL6/J NIA Aging mouse colony NIA N/A 5xFAD (B6SJL-Tg(APPSwFlLon, PSEN1*M146L*L286V)6799Vas/Mmjax) The Jackson Laboratory/ MMRRC MMRRC Strain#034840-JAX B6;129-Gt(ROSA) 26Sortm1(CAG-cas9*,-EGFP)Fezh/J The Jackson Laboratory Strain#024857 Oligonucleotides Gpld1 qPCR FWD: GGAAGCAGAGAGGAATTGTGGC Horowitz et al.16 N/A Gpld1 qPCR REV: TCCAAACCACGAGAAGTCCTCC Horowitz et al.16 N/A Gapdh qPCR FWD: GGGTGTGAACCACGAGAAAT This paper N/A Gapdh qPCR REV: ACTGTGGTCATGAGCCCTTC This paper N/A GPLD1 qPCR FWD (human) This paper N/A GPLD1 qPCR REV (human) This paper N/A Alpl qPCR FWD: GAACAGACCCTCCCCACGAG This paper N/A Alpl qPCR REV: GTGCCGATGGCCAGTACTAA This paper N/A Alpl qPCR FWD2: TAACACCAACGCTCAGGTCC This paper N/A Alpl qPCR REV2: TGGATGTGACCTCATTGCCC This paper N/A Recombinant DNA pAAV2/8 Addgene Plasmid#112864 pUCmini-iCAP-PHP.V1 Addgene Plasmid#127847 pAAV-CAG-mRuby2 Addgene Plasmid#99123 pEMS1938 Addgene Plasmid#82563 pAdDeltaF6 Addgene Plasmid#112867 pMD2.G Addgene Plasmid#12259 psPAX2 Addgene Plasmid#12260 lentiCRISPR v2 Addgene Plasmid#52961 pTB CMV Gpld1 IRES eGFP Horowitz et al.16 N/A pTB CMV Gpld1 H133N IRES eGFP Horowitz et al.16 N/A pTB CMV Gpld1 H158N IRES eGFP Horowitz et al.16 N/A pTB CMV IRES eGFP Horowitz et al.16 N/A pTB CMV Alpl IRES eGFP This paper N/A pTB CMV GPLD1 (human) IRES eGFP This paper N/A pAAV-CAG-Alpl This paper N/A pAAV-CRE-hU6-gRNA This paper N/A pAAV TBG eGFP This paper N/A (Continued on next page) ll OPEN ACCESS e2 Cell 189, 1–18.e1–e9, March 5, 2026 Please cite this article in press as: Bieri et al., Liver exerkine reverses aging- and Alzheimer’s-related memory loss via vasculature, Cell (2026), https://doi.org/10.1016/j.cell.2026.01.024 Article

    RNA Sequencing:

    Article Title: Liver exerkine reverses aging- and Alzheimer's-related memory loss via vasculature.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER PureLink RNA Mini kit Thermo Fisher Cat#12183025 Direct-zolTM RNA Purification Kit, Miniprep Plus Zymo Research Cat#R2072 High Capacity cDNA Reverse Transcription kit Thermo Fisher Cat#4374966 PowerUp SYBR Green Master Mix Thermo Fisher Cat#A25742 ZebaTM Spin Desalting Columns, 7K MWCO, 5 mL Thermo Fisher Cat#89892 Miltenyi Neural Dissociation Kits (P) Miltenyi Cat#130-092-628 Deposited data Single-nucleus RNA sequencing data This paper GEO: GSE304483 BEC single-cell RNA sequencing data This paper GEO: GSE269061 Experimental models: Cell lines 293T ATCC Cat#CRL-3216; RRID: CVCL_0063 Neuro-2a ATCC Cat#CCL-131; RRID: CVCL_0470 Experimental models: Organisms/strains C57BL/6J The Jackson Laboratory Strain#000664 C57BlL6/J NIA Aging mouse colony NIA N/A 5xFAD (B6SJL-Tg(APPSwFlLon, PSEN1*M146L*L286V)6799Vas/Mmjax) The Jackson Laboratory/ MMRRC MMRRC Strain#034840-JAX B6;129-Gt(ROSA) 26Sortm1(CAG-cas9*,-EGFP)Fezh/J The Jackson Laboratory Strain#024857 Oligonucleotides Gpld1 qPCR FWD: GGAAGCAGAGAGGAATTGTGGC Horowitz et al.16 N/A Gpld1 qPCR REV: TCCAAACCACGAGAAGTCCTCC Horowitz et al.16 N/A Gapdh qPCR FWD: GGGTGTGAACCACGAGAAAT This paper N/A Gapdh qPCR REV: ACTGTGGTCATGAGCCCTTC This paper N/A GPLD1 qPCR FWD (human) This paper N/A GPLD1 qPCR REV (human) This paper N/A Alpl qPCR FWD: GAACAGACCCTCCCCACGAG This paper N/A Alpl qPCR REV: GTGCCGATGGCCAGTACTAA This paper N/A Alpl qPCR FWD2: TAACACCAACGCTCAGGTCC This paper N/A Alpl qPCR REV2: TGGATGTGACCTCATTGCCC This paper N/A Recombinant DNA pAAV2/8 Addgene Plasmid#112864 pUCmini-iCAP-PHP.V1 Addgene Plasmid#127847 pAAV-CAG-mRuby2 Addgene Plasmid#99123 pEMS1938 Addgene Plasmid#82563 pAdDeltaF6 Addgene Plasmid#112867 pMD2.G Addgene Plasmid#12259 psPAX2 Addgene Plasmid#12260 lentiCRISPR v2 Addgene Plasmid#52961 pTB CMV Gpld1 IRES eGFP Horowitz et al.16 N/A pTB CMV Gpld1 H133N IRES eGFP Horowitz et al.16 N/A pTB CMV Gpld1 H158N IRES eGFP Horowitz et al.16 N/A pTB CMV IRES eGFP Horowitz et al.16 N/A pTB CMV Alpl IRES eGFP This paper N/A pTB CMV GPLD1 (human) IRES eGFP This paper N/A pAAV-CAG-Alpl This paper N/A pAAV-CRE-hU6-gRNA This paper N/A pAAV TBG eGFP This paper N/A (Continued on next page) ll OPEN ACCESS e2 Cell 189, 1–18.e1–e9, March 5, 2026 Please cite this article in press as: Bieri et al., Liver exerkine reverses aging- and Alzheimer’s-related memory loss via vasculature, Cell (2026), https://doi.org/10.1016/j.cell.2026.01.024 Article

    Single Cell:

    Article Title: Liver exerkine reverses aging- and Alzheimer's-related memory loss via vasculature.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER PureLink RNA Mini kit Thermo Fisher Cat#12183025 Direct-zolTM RNA Purification Kit, Miniprep Plus Zymo Research Cat#R2072 High Capacity cDNA Reverse Transcription kit Thermo Fisher Cat#4374966 PowerUp SYBR Green Master Mix Thermo Fisher Cat#A25742 ZebaTM Spin Desalting Columns, 7K MWCO, 5 mL Thermo Fisher Cat#89892 Miltenyi Neural Dissociation Kits (P) Miltenyi Cat#130-092-628 Deposited data Single-nucleus RNA sequencing data This paper GEO: GSE304483 BEC single-cell RNA sequencing data This paper GEO: GSE269061 Experimental models: Cell lines 293T ATCC Cat#CRL-3216; RRID: CVCL_0063 Neuro-2a ATCC Cat#CCL-131; RRID: CVCL_0470 Experimental models: Organisms/strains C57BL/6J The Jackson Laboratory Strain#000664 C57BlL6/J NIA Aging mouse colony NIA N/A 5xFAD (B6SJL-Tg(APPSwFlLon, PSEN1*M146L*L286V)6799Vas/Mmjax) The Jackson Laboratory/ MMRRC MMRRC Strain#034840-JAX B6;129-Gt(ROSA) 26Sortm1(CAG-cas9*,-EGFP)Fezh/J The Jackson Laboratory Strain#024857 Oligonucleotides Gpld1 qPCR FWD: GGAAGCAGAGAGGAATTGTGGC Horowitz et al.16 N/A Gpld1 qPCR REV: TCCAAACCACGAGAAGTCCTCC Horowitz et al.16 N/A Gapdh qPCR FWD: GGGTGTGAACCACGAGAAAT This paper N/A Gapdh qPCR REV: ACTGTGGTCATGAGCCCTTC This paper N/A GPLD1 qPCR FWD (human) This paper N/A GPLD1 qPCR REV (human) This paper N/A Alpl qPCR FWD: GAACAGACCCTCCCCACGAG This paper N/A Alpl qPCR REV: GTGCCGATGGCCAGTACTAA This paper N/A Alpl qPCR FWD2: TAACACCAACGCTCAGGTCC This paper N/A Alpl qPCR REV2: TGGATGTGACCTCATTGCCC This paper N/A Recombinant DNA pAAV2/8 Addgene Plasmid#112864 pUCmini-iCAP-PHP.V1 Addgene Plasmid#127847 pAAV-CAG-mRuby2 Addgene Plasmid#99123 pEMS1938 Addgene Plasmid#82563 pAdDeltaF6 Addgene Plasmid#112867 pMD2.G Addgene Plasmid#12259 psPAX2 Addgene Plasmid#12260 lentiCRISPR v2 Addgene Plasmid#52961 pTB CMV Gpld1 IRES eGFP Horowitz et al.16 N/A pTB CMV Gpld1 H133N IRES eGFP Horowitz et al.16 N/A pTB CMV Gpld1 H158N IRES eGFP Horowitz et al.16 N/A pTB CMV IRES eGFP Horowitz et al.16 N/A pTB CMV Alpl IRES eGFP This paper N/A pTB CMV GPLD1 (human) IRES eGFP This paper N/A pAAV-CAG-Alpl This paper N/A pAAV-CRE-hU6-gRNA This paper N/A pAAV TBG eGFP This paper N/A (Continued on next page) ll OPEN ACCESS e2 Cell 189, 1–18.e1–e9, March 5, 2026 Please cite this article in press as: Bieri et al., Liver exerkine reverses aging- and Alzheimer’s-related memory loss via vasculature, Cell (2026), https://doi.org/10.1016/j.cell.2026.01.024 Article

    Real-time Polymerase Chain Reaction:

    Article Title: Liver exerkine reverses aging- and Alzheimer's-related memory loss via vasculature.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER PureLink RNA Mini kit Thermo Fisher Cat#12183025 Direct-zolTM RNA Purification Kit, Miniprep Plus Zymo Research Cat#R2072 High Capacity cDNA Reverse Transcription kit Thermo Fisher Cat#4374966 PowerUp SYBR Green Master Mix Thermo Fisher Cat#A25742 ZebaTM Spin Desalting Columns, 7K MWCO, 5 mL Thermo Fisher Cat#89892 Miltenyi Neural Dissociation Kits (P) Miltenyi Cat#130-092-628 Deposited data Single-nucleus RNA sequencing data This paper GEO: GSE304483 BEC single-cell RNA sequencing data This paper GEO: GSE269061 Experimental models: Cell lines 293T ATCC Cat#CRL-3216; RRID: CVCL_0063 Neuro-2a ATCC Cat#CCL-131; RRID: CVCL_0470 Experimental models: Organisms/strains C57BL/6J The Jackson Laboratory Strain#000664 C57BlL6/J NIA Aging mouse colony NIA N/A 5xFAD (B6SJL-Tg(APPSwFlLon, PSEN1*M146L*L286V)6799Vas/Mmjax) The Jackson Laboratory/ MMRRC MMRRC Strain#034840-JAX B6;129-Gt(ROSA) 26Sortm1(CAG-cas9*,-EGFP)Fezh/J The Jackson Laboratory Strain#024857 Oligonucleotides Gpld1 qPCR FWD: GGAAGCAGAGAGGAATTGTGGC Horowitz et al.16 N/A Gpld1 qPCR REV: TCCAAACCACGAGAAGTCCTCC Horowitz et al.16 N/A Gapdh qPCR FWD: GGGTGTGAACCACGAGAAAT This paper N/A Gapdh qPCR REV: ACTGTGGTCATGAGCCCTTC This paper N/A GPLD1 qPCR FWD (human) This paper N/A GPLD1 qPCR REV (human) This paper N/A Alpl qPCR FWD: GAACAGACCCTCCCCACGAG This paper N/A Alpl qPCR REV: GTGCCGATGGCCAGTACTAA This paper N/A Alpl qPCR FWD2: TAACACCAACGCTCAGGTCC This paper N/A Alpl qPCR REV2: TGGATGTGACCTCATTGCCC This paper N/A Recombinant DNA pAAV2/8 Addgene Plasmid#112864 pUCmini-iCAP-PHP.V1 Addgene Plasmid#127847 pAAV-CAG-mRuby2 Addgene Plasmid#99123 pEMS1938 Addgene Plasmid#82563 pAdDeltaF6 Addgene Plasmid#112867 pMD2.G Addgene Plasmid#12259 psPAX2 Addgene Plasmid#12260 lentiCRISPR v2 Addgene Plasmid#52961 pTB CMV Gpld1 IRES eGFP Horowitz et al.16 N/A pTB CMV Gpld1 H133N IRES eGFP Horowitz et al.16 N/A pTB CMV Gpld1 H158N IRES eGFP Horowitz et al.16 N/A pTB CMV IRES eGFP Horowitz et al.16 N/A pTB CMV Alpl IRES eGFP This paper N/A pTB CMV GPLD1 (human) IRES eGFP This paper N/A pAAV-CAG-Alpl This paper N/A pAAV-CRE-hU6-gRNA This paper N/A pAAV TBG eGFP This paper N/A (Continued on next page) ll OPEN ACCESS e2 Cell 189, 1–18.e1–e9, March 5, 2026 Please cite this article in press as: Bieri et al., Liver exerkine reverses aging- and Alzheimer’s-related memory loss via vasculature, Cell (2026), https://doi.org/10.1016/j.cell.2026.01.024 Article

    Recombinant:

    Article Title: Liver exerkine reverses aging- and Alzheimer's-related memory loss via vasculature.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER PureLink RNA Mini kit Thermo Fisher Cat#12183025 Direct-zolTM RNA Purification Kit, Miniprep Plus Zymo Research Cat#R2072 High Capacity cDNA Reverse Transcription kit Thermo Fisher Cat#4374966 PowerUp SYBR Green Master Mix Thermo Fisher Cat#A25742 ZebaTM Spin Desalting Columns, 7K MWCO, 5 mL Thermo Fisher Cat#89892 Miltenyi Neural Dissociation Kits (P) Miltenyi Cat#130-092-628 Deposited data Single-nucleus RNA sequencing data This paper GEO: GSE304483 BEC single-cell RNA sequencing data This paper GEO: GSE269061 Experimental models: Cell lines 293T ATCC Cat#CRL-3216; RRID: CVCL_0063 Neuro-2a ATCC Cat#CCL-131; RRID: CVCL_0470 Experimental models: Organisms/strains C57BL/6J The Jackson Laboratory Strain#000664 C57BlL6/J NIA Aging mouse colony NIA N/A 5xFAD (B6SJL-Tg(APPSwFlLon, PSEN1*M146L*L286V)6799Vas/Mmjax) The Jackson Laboratory/ MMRRC MMRRC Strain#034840-JAX B6;129-Gt(ROSA) 26Sortm1(CAG-cas9*,-EGFP)Fezh/J The Jackson Laboratory Strain#024857 Oligonucleotides Gpld1 qPCR FWD: GGAAGCAGAGAGGAATTGTGGC Horowitz et al.16 N/A Gpld1 qPCR REV: TCCAAACCACGAGAAGTCCTCC Horowitz et al.16 N/A Gapdh qPCR FWD: GGGTGTGAACCACGAGAAAT This paper N/A Gapdh qPCR REV: ACTGTGGTCATGAGCCCTTC This paper N/A GPLD1 qPCR FWD (human) This paper N/A GPLD1 qPCR REV (human) This paper N/A Alpl qPCR FWD: GAACAGACCCTCCCCACGAG This paper N/A Alpl qPCR REV: GTGCCGATGGCCAGTACTAA This paper N/A Alpl qPCR FWD2: TAACACCAACGCTCAGGTCC This paper N/A Alpl qPCR REV2: TGGATGTGACCTCATTGCCC This paper N/A Recombinant DNA pAAV2/8 Addgene Plasmid#112864 pUCmini-iCAP-PHP.V1 Addgene Plasmid#127847 pAAV-CAG-mRuby2 Addgene Plasmid#99123 pEMS1938 Addgene Plasmid#82563 pAdDeltaF6 Addgene Plasmid#112867 pMD2.G Addgene Plasmid#12259 psPAX2 Addgene Plasmid#12260 lentiCRISPR v2 Addgene Plasmid#52961 pTB CMV Gpld1 IRES eGFP Horowitz et al.16 N/A pTB CMV Gpld1 H133N IRES eGFP Horowitz et al.16 N/A pTB CMV Gpld1 H158N IRES eGFP Horowitz et al.16 N/A pTB CMV IRES eGFP Horowitz et al.16 N/A pTB CMV Alpl IRES eGFP This paper N/A pTB CMV GPLD1 (human) IRES eGFP This paper N/A pAAV-CAG-Alpl This paper N/A pAAV-CRE-hU6-gRNA This paper N/A pAAV TBG eGFP This paper N/A (Continued on next page) ll OPEN ACCESS e2 Cell 189, 1–18.e1–e9, March 5, 2026 Please cite this article in press as: Bieri et al., Liver exerkine reverses aging- and Alzheimer’s-related memory loss via vasculature, Cell (2026), https://doi.org/10.1016/j.cell.2026.01.024 Article

    Plasmid Preparation:

    Article Title: Liver exerkine reverses aging- and Alzheimer's-related memory loss via vasculature.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER PureLink RNA Mini kit Thermo Fisher Cat#12183025 Direct-zolTM RNA Purification Kit, Miniprep Plus Zymo Research Cat#R2072 High Capacity cDNA Reverse Transcription kit Thermo Fisher Cat#4374966 PowerUp SYBR Green Master Mix Thermo Fisher Cat#A25742 ZebaTM Spin Desalting Columns, 7K MWCO, 5 mL Thermo Fisher Cat#89892 Miltenyi Neural Dissociation Kits (P) Miltenyi Cat#130-092-628 Deposited data Single-nucleus RNA sequencing data This paper GEO: GSE304483 BEC single-cell RNA sequencing data This paper GEO: GSE269061 Experimental models: Cell lines 293T ATCC Cat#CRL-3216; RRID: CVCL_0063 Neuro-2a ATCC Cat#CCL-131; RRID: CVCL_0470 Experimental models: Organisms/strains C57BL/6J The Jackson Laboratory Strain#000664 C57BlL6/J NIA Aging mouse colony NIA N/A 5xFAD (B6SJL-Tg(APPSwFlLon, PSEN1*M146L*L286V)6799Vas/Mmjax) The Jackson Laboratory/ MMRRC MMRRC Strain#034840-JAX B6;129-Gt(ROSA) 26Sortm1(CAG-cas9*,-EGFP)Fezh/J The Jackson Laboratory Strain#024857 Oligonucleotides Gpld1 qPCR FWD: GGAAGCAGAGAGGAATTGTGGC Horowitz et al.16 N/A Gpld1 qPCR REV: TCCAAACCACGAGAAGTCCTCC Horowitz et al.16 N/A Gapdh qPCR FWD: GGGTGTGAACCACGAGAAAT This paper N/A Gapdh qPCR REV: ACTGTGGTCATGAGCCCTTC This paper N/A GPLD1 qPCR FWD (human) This paper N/A GPLD1 qPCR REV (human) This paper N/A Alpl qPCR FWD: GAACAGACCCTCCCCACGAG This paper N/A Alpl qPCR REV: GTGCCGATGGCCAGTACTAA This paper N/A Alpl qPCR FWD2: TAACACCAACGCTCAGGTCC This paper N/A Alpl qPCR REV2: TGGATGTGACCTCATTGCCC This paper N/A Recombinant DNA pAAV2/8 Addgene Plasmid#112864 pUCmini-iCAP-PHP.V1 Addgene Plasmid#127847 pAAV-CAG-mRuby2 Addgene Plasmid#99123 pEMS1938 Addgene Plasmid#82563 pAdDeltaF6 Addgene Plasmid#112867 pMD2.G Addgene Plasmid#12259 psPAX2 Addgene Plasmid#12260 lentiCRISPR v2 Addgene Plasmid#52961 pTB CMV Gpld1 IRES eGFP Horowitz et al.16 N/A pTB CMV Gpld1 H133N IRES eGFP Horowitz et al.16 N/A pTB CMV Gpld1 H158N IRES eGFP Horowitz et al.16 N/A pTB CMV IRES eGFP Horowitz et al.16 N/A pTB CMV Alpl IRES eGFP This paper N/A pTB CMV GPLD1 (human) IRES eGFP This paper N/A pAAV-CAG-Alpl This paper N/A pAAV-CRE-hU6-gRNA This paper N/A pAAV TBG eGFP This paper N/A (Continued on next page) ll OPEN ACCESS e2 Cell 189, 1–18.e1–e9, March 5, 2026 Please cite this article in press as: Bieri et al., Liver exerkine reverses aging- and Alzheimer’s-related memory loss via vasculature, Cell (2026), https://doi.org/10.1016/j.cell.2026.01.024 Article



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    recombinant dna reagent aav1 cagflex mruby2 gsg p2agcamp6fwpre pa addgene  (Addgene inc)
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